Prediction of Mortality Risk After Ischemic Acute Kidney Injury With a Novel Prognostic Model: A Multivariable Prediction Model Development and Validation Study

Mei Wang; Ping Yan; Ning-Ya Zhang; Ying-Hao Deng; Xiao-Qin Luo; Xiu-Fen Wang; Shao-Bin Duan

doi:10.3389/fmed.2022.892473

Prediction of Mortality Risk After Ischemic Acute Kidney Injury With a Novel Prognostic Model: A Multivariable Prediction Model Development and Validation Study

Front Med (Lausanne). 2022 Aug 15:9:892473. doi: 10.3389/fmed.2022.892473. eCollection 2022.

Authors

Mei Wang¹, Ping Yan¹, Ning-Ya Zhang², Ying-Hao Deng¹, Xiao-Qin Luo¹, Xiu-Fen Wang¹, Shao-Bin Duan¹

Affiliations

¹ Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, China.
² Information Center, The Second Xiangya Hospital of Central South University, Changsha, China.

Abstract

Background and objectives: Acute kidney injury (AKI) that results from ischemia is a common clinical syndrome and correlates with high morbidity and mortality among hospitalized patients. However, a clinical tool to predict mortality risk of ischemic AKI is not available. In this study, we aimed to develop and validate models to predict the 30-day and 1-year mortality risk of hospitalized patients with ischemic AKI.

Methods: A total of 1,836 admissions with ischemic AKI were recruited from 277,898 inpatients admitted to three affiliated tertiary general hospitals of Central South University in China between January 2015 and December 2015. Patients in the final analysis were followed up for 1 year. Study patients were randomly divided in a 7:3 ratio to form the training cohort and validation cohort. Multivariable regression analyses were used for developing mortality prediction models.

Results: Hepatorenal syndrome, shock, central nervous system failure, Charlson comorbidity index (≥2 points), mechanical ventilation, renal function at discharge were independent risk factors for 30-day mortality after ischemic AKI, while malignancy, sepsis, heart failure, liver failure, Charlson comorbidity index (≥2 points), mechanical ventilation, and renal function at discharge were predictors for 1-year mortality. The area under the receiver operating characteristic curves (AUROCs) of 30-day prediction model were 0.878 (95% confidence interval (CI): 0.849-0.908) in the training cohort and 0.867 (95% CI: 0.820-0.913) in the validation cohort. The AUROCs of the 1-year mortality prediction in the training and validation cohort were 0.803 (95% CI: 0.772-0.834) and 0.788 (95% CI: 0.741-0.835), respectively.

Conclusion: Our easily applied prediction models can effectively identify individuals at high mortality risk within 30 days or 1 year in hospitalized patients with ischemic AKI. It can guide the optimal clinical management to minimize mortality after an episode of ischemic AKI.

Keywords: acute kidney injury; ischemia; mortality; prognostic model; risk factor.