Stereotactic body radiotherapy to defer systemic therapy in patients with oligorecurrent disease

Jonas Willmann; Eugenia Vlaskou Badra; Selma Adilovic; Sebastian M Christ; Maiwand Ahmadsei; Michael Mayinger; Matthias Guckenberger; Nicolaus Andratschke

doi:10.1016/j.ctro.2022.08.008

Stereotactic body radiotherapy to defer systemic therapy in patients with oligorecurrent disease

Clin Transl Radiat Oncol. 2022 Aug 19:37:12-18. doi: 10.1016/j.ctro.2022.08.008. eCollection 2022 Nov.

Authors

Jonas Willmann¹, Eugenia Vlaskou Badra¹, Selma Adilovic¹, Sebastian M Christ¹, Maiwand Ahmadsei¹, Michael Mayinger¹, Matthias Guckenberger¹, Nicolaus Andratschke¹

Affiliation

¹ Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Abstract

Background: Patients who develop oligorecurrent disease may be treated with metastasis-directed stereotactic body radiotherapy (SBRT) to defer the start of systemic therapy and delay its potential side effects. We report oncological outcomes and patterns of failure in patients with oligorecurrent disease treated with SBRT and determine which factors impact the interval to initiation of systemic therapy.

Material/methods: This retrospective study included patients with oligorecurrent disease (≤5 lesions) from any solid organ malignancy, treated with SBRT to all metastases and no systemic therapy for a minimum one month after SBRT between 01/2014 and 12/2019. The Kaplan-Meier method was used to analyze overall survival (OS) and progression-free survival (PFS), and the cumulative incidence of initiation of systemic therapy was analyzed assuming death without systemic therapy as a competing risk. Univariable and multivariable analyses are used to assess predictors of the systemic therapy-free interval.

Results: Among 545 patients treated with SBRT for oligometastatic disease, 142 patients were treated with SBRT only for oligorecurrent disease. The most common primary tumors were lung and gastrointestinal cancer in 47 (33.1 %) and 28 (19.7 %) patients, respectively. After a median follow-up of 25 months, the median PFS and OS was 6.1 months and 48.9 months, respectively. Distant metastases were the most common first failure, and oligometastatic distant failure occured in 86 patients (60.6 %). New metastases were treated with repeat SBRT in 48 patients (33.8 %). The 1- and 2-year cumulative incidence of initiation of systemic therapy was 24.6 % and 36.8 %, respectively. In multivariable analysis, the number of previous lines of systemic therapy and the cumulative volume of metastases were significantly associated with the interval to initiation of systemic therapy.

Conclusion: Selected patients with oligorecurrence achieved favorable OS and low cumulative incidence of initiation of systemic therapy. Prospective studies are warranted to determine how the deferral of systemic therapy impacts OS compared with immediate systemic therapy in combination with SBRT.

Keywords: Oligometastatic Disease; Oligorecurrent Disease; Stereotactic Body Radiotherapy; Systemic Therapy-Free Interval.