Long-term prognosis in addiction on sedative and hypnotic drugs analyzed with the Cox regression model

Acta Psychiatr Scand. 1987 May;75(5):521-31. doi: 10.1111/j.1600-0447.1987.tb02828.x.


The prognosis of 221 patients first admitted in 1941-1954 for dependence on sedative-hypnotic drugs was determined in a record-linkage and interview study concluded in 1984. Different outcomes were related to admission characteristics by means of the Cox proportional hazards regression model. An excess of unnatural deaths was noted; suicides in 11% of the men and 23% of the women. Of those with primary sedative-hypnotic dependence, 46% continued to abuse drugs till death or follow-up, and of those with a primary or concomitant alcohol abuse 72%. An unfavorable outcome was significantly related to primary psychiatric symptoms before the first admission, concomitant alcohol abuse, familial drug and alcohol abuse and health care occupation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcoholism / complications
  • Female
  • Humans
  • Hypnotics and Sedatives*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prognosis
  • Regression Analysis
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / mortality
  • Substance-Related Disorders / psychology*
  • Suicide / epidemiology
  • Sweden


  • Hypnotics and Sedatives