Contemporary Applications of Machine Learning for Device Therapy in Heart Failure

JACC Heart Fail. 2022 Sep;10(9):603-622. doi: 10.1016/j.jchf.2022.06.011.


Despite a better understanding of the underlying pathogenesis of heart failure (HF), pharmacotherapy, surgical, and percutaneous interventions do not prevent disease progression in all patients, and a significant proportion of patients end up requiring advanced therapies. Machine learning (ML) is gaining wider acceptance in cardiovascular medicine because of its ability to incorporate large, complex, and multidimensional data and to potentially facilitate the creation of predictive models not constrained by many of the limitations of traditional statistical approaches. With the coexistence of "big data" and novel advanced analytic techniques using ML, there is ever-increasing research into applying ML in the context of HF with the goal of improving patient outcomes. Through this review, the authors describe the basics of ML and summarize the existing published reports regarding contemporary applications of ML in device therapy for HF while highlighting the limitations to widespread implementation and its future promises.

Keywords: cardiac resynchronization therapy; echocardiography; heart failure; left ventricular assist device; machine learning; transcatheter edge-to-edge repair.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiovascular Agents*
  • Heart Failure* / therapy
  • Humans
  • Machine Learning
  • Stroke Volume


  • Cardiovascular Agents