Fission impossible: Mitochondrial dynamics direct muscle stem cell fates

Cell Stem Cell. 2022 Sep 1;29(9):1287-1289. doi: 10.1016/j.stem.2022.08.010.


Muscle stem cells (MuSCs) exhibit different metabolic profiles depending on their activity, however the mechanisms by which mitochondria affect MuSC fate has been understudied. In this issue of Cell Stem Cell, Hong et al. (2022) and Baker et al. (2022) demonstrate that defects in mitochondrial dynamics hinder proper MuSC activation and impair muscle regeneration.

Publication types

  • Comment

MeSH terms

  • Mitochondrial Dynamics*
  • Muscle, Skeletal*
  • Myoblasts / metabolism