The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation

Hyllana C D Medeiros; Sophia Y Lunt

doi:10.1016/j.molcel.2022.08.004

The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation

Mol Cell. 2022 Sep 1;82(17):3119-3121. doi: 10.1016/j.molcel.2022.08.004.

Authors

Hyllana C D Medeiros¹, Sophia Y Lunt²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
² Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA. Electronic address: sophia@msu.edu.

Abstract

In this issue of Molecular Cell, Wang et al. investigate the Warburg effect in proliferating cells and demonstrate that lactate fermentation is a secondary mechanism activated after mitochondrial shuttles exceed their capacity to oxidize cytosolic NADH.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Fermentation
Glycolysis
Lactates / metabolism
Mitochondria* / metabolism
NAD* / metabolism
Oxidation-Reduction

Substances

Lactates
NAD

Abstract

Publication types

MeSH terms

Substances

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