Midazolam as an induction agent in children: a pharmacokinetic and clinical study

Anesth Analg. 1987 Jul;66(7):625-8.


The pharmacokinetics of midazolam was studied in 21 children undergoing elective surgery at five different dose levels for induction of general anesthesia and were compared with a control group (n = 6) given thiopental, 5 mg/kg. The clearance of midazolam was found to be dose-related. The elimination half-life varied from 0.79 to 2.83 hr, which is shorter than in adult patients. Even a dose of 0.6 mg/kg midazolam was found to be unreliable as an agent for induction of anesthesia. Compared with thiopental 5 mg/kg, significantly longer times of onset to closing of the eyes (P less than 0.01) and the disappearance of eyelid reflex (P less than 0.01) were seen with midazolam.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Anesthesia, General / methods
  • Child
  • Dose-Response Relationship, Drug
  • Humans
  • Kinetics
  • Midazolam / blood*
  • Preanesthetic Medication*
  • Regression Analysis
  • Thiopental
  • Time Factors


  • Thiopental
  • Midazolam