HOTAIR in solid tumors: Emerging mechanisms and clinical strategies

Xiangchen An; Yili Liu

doi:10.1016/j.biopha.2022.113594

HOTAIR in solid tumors: Emerging mechanisms and clinical strategies

Biomed Pharmacother. 2022 Oct:154:113594. doi: 10.1016/j.biopha.2022.113594. Epub 2022 Aug 31.

Authors

Xiangchen An¹, Yili Liu²

Affiliations

¹ Department of Urology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
² Department of Urology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China. Electronic address: 2018120337@cmu.edu.cn.

PMID: 36057218
DOI: 10.1016/j.biopha.2022.113594

Abstract

Long non-coding RNAs (lncRNAs) play a critical role in several human diseases, particularly in solid tumors. Specific lncRNAs are effective biological molecular markers for diagnosing diseases and determining patient prognosis for designing molecularly targeted therapies. HOTAIR is reportedly involved in several physiological emerging processes in solid tumor, such as unlocking phenotypic plasticity, polymorphic microbiome, and cellular senescence, and has been implicated in tumorigenesis and progression. This review summarizes the relationship between the levels of expression, biological features, clinical symptoms, and regulatory mechanisms of HOTAIR action in solid cancers and discusses the clinical applicability of HOTAIR as a biomarker for predicting risk, diagnosis, prognosis, and designing targeted therapy for cancer.

Keywords: Biomarker; Cellular senescence; HOTAIR; Phenotypic plasticity; Polymorphic microbiome; Solid tumors.

Publication types

Review

MeSH terms

Carcinogenesis
Gene Expression Regulation, Neoplastic
Humans
Molecular Targeted Therapy
Neoplasms* / diagnosis
Neoplasms* / drug therapy
Neoplasms* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding