GBA1 and The Immune System: A Potential Role in Parkinson's Disease?

J Parkinsons Dis. 2022;12(s1):S53-S64. doi: 10.3233/JPD-223423.

Abstract

It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5-20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation. In this review, we discuss these different pieces of evidence and whether the interplay between GBA1 and the immune system may have a role in PD.

Keywords: GBA1; Gaucher disease; Parkinson’s disease; immune response; inflammation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glucosylceramidase* / genetics
  • Humans
  • Immune System
  • Inflammation
  • Mutation
  • Parkinson Disease* / genetics

Substances

  • Glucosylceramidase