Anti-colorectal cancer effects of seaweed-derived bioactive compounds

doi:10.3389/fmed.2022.988507

Review

. 2022 Aug 19:9:988507.

doi: 10.3389/fmed.2022.988507. eCollection 2022.

Anti-colorectal cancer effects of seaweed-derived bioactive compounds

Yunhua Fu¹, Dong Xie¹, Yinghao Zhu¹, Xinyue Zhang², Hao Yue¹, Kai Zhu¹, Zifeng Pi¹, Yulin Dai¹

Affiliations

PMID: 36059851
PMCID: PMC9437318
DOI: 10.3389/fmed.2022.988507

Free PMC article

Review

Anti-colorectal cancer effects of seaweed-derived bioactive compounds

Yunhua Fu et al. Front Med (Lausanne). 2022.

Free PMC article

. 2022 Aug 19:9:988507.

doi: 10.3389/fmed.2022.988507. eCollection 2022.

Authors

Yunhua Fu¹, Dong Xie¹, Yinghao Zhu¹, Xinyue Zhang², Hao Yue¹, Kai Zhu¹, Zifeng Pi¹, Yulin Dai¹

Affiliations

¹ Changchun University of Chinese Medicine, Changchun, China.
² Jilin Academy of Agricultural Machinery, Changchun, China.

PMID: 36059851
PMCID: PMC9437318
DOI: 10.3389/fmed.2022.988507

Abstract

Seaweeds are classified as Chlorophyta, Rhodophyta, and Phaeophyta. They constitute a number of the most significant repositories of new therapeutic compounds for human use. Seaweed has been proven to possess diverse bioactive properties, which include anticancer properties. The present review focuses on colorectal cancer, which is a primary cause of cancer-related mortality in humans. In addition, it discusses various compounds derived from a series of seaweeds that have been shown to eradicate or slow the progression of cancer. Therapeutic compounds extracted from seaweed have shown activity against colorectal cancer. Furthermore, the mechanisms through which these compounds can induce apoptosis in vitro and in vivo were reviewed. This review emphasizes the potential utility of seaweeds as anticancer agents through the consideration of the capability of compounds present in seaweeds to fight against colorectal cancer.

Keywords: Chlorophyta; Phaeophyta; Rhodophyta; colorectal cancer; therapeutic compounds.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. . Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2021) 71:209–49. 10.3322/caac.21660 - DOI - PubMed

[2] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. . Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2021) 71:209–49. 10.3322/caac.21660 - DOI - PubMed

[3] Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. (2019) 14:89–103. 10.5114/pg.2018.81072 - DOI - PMC - PubMed

[4] Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. (2019) 14:89–103. 10.5114/pg.2018.81072 - DOI - PMC - PubMed

[5] Zbakh H, Zubia E, Reyes CL, Calderon-Montano JM, Motilva V. Anticancer activities of meroterpenoids isolated from the brown alga cystoseira usneoides against the human colon cancer cells Ht-29. Foods. (2020) 9:300. 10.3390/foods9030300 - DOI - PMC - PubMed

[6] Zbakh H, Zubia E, Reyes CL, Calderon-Montano JM, Motilva V. Anticancer activities of meroterpenoids isolated from the brown alga cystoseira usneoides against the human colon cancer cells Ht-29. Foods. (2020) 9:300. 10.3390/foods9030300 - DOI - PMC - PubMed

[7] Davis CD, Milner JA. Molecular targets for nutritional preemption of cancer. Curr Cancer Drug Targets. (2007) 7:410–5. 10.2174/156800907781386560 - DOI - PubMed

[8] Davis CD, Milner JA. Molecular targets for nutritional preemption of cancer. Curr Cancer Drug Targets. (2007) 7:410–5. 10.2174/156800907781386560 - DOI - PubMed

[9] Huang G, Liu Z, He L, Luk KH, Cheung ST, Wong KH, et al. . Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity. Biomater Sci. (2018) 6:2508–17. 10.1039/C8BM00670A - DOI - PubMed

[10] Huang G, Liu Z, He L, Luk KH, Cheung ST, Wong KH, et al. . Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity. Biomater Sci. (2018) 6:2508–17. 10.1039/C8BM00670A - DOI - PubMed

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Anti-colorectal cancer effects of seaweed-derived bioactive compounds

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Anti-colorectal cancer effects of seaweed-derived bioactive compounds

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