Bioactive natural products in COVID-19 therapy

Front Pharmacol. 2022 Aug 19;13:926507. doi: 10.3389/fphar.2022.926507. eCollection 2022.


The devastating COVID-19 pandemic has caused more than six million deaths worldwide during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic bullets still do not exist. Numerous natural products (cordycepin, gallinamide A, plitidepsin, telocinobufagin, and tylophorine) have been widely studied and play a potential function in treating COVID-19. In this paper, we reviewed published studies (from May 2021 to April 2022) relating closely to bioactive natural products (isolated from medicinal plants, animals products, and marine organisms) in COVID-19 therapy in vitro to provide some essential guidance for anti-SARS-CoV-2 drug research and development.

Keywords: COVID-19; SARS-CoV-2; cordycepin; gallinamide A; natural products; plitidepsin; telocinobufagin; tylophorine.

Publication types

  • Review