Multiple sclerosis disease activity correlates with gadolinium-enhanced magnetic resonance imaging

Ann Neurol. 1987 Mar;21(3):300-6. doi: 10.1002/ana.410210312.


Magnetic resonance imaging provides a method of visualizing multiple sclerosis plaques, but the age and activity of these plaques cannot be determined with routine magnetic resonance images. Gadolinium DTPA is a paramagnetic contrast agent that does not cross an intact blood-brain barrier. We studied 16 patients with multiple sclerosis, using magnetic resonance imaging, gadolinium-enhanced magnetic resonance imaging, and computed tomographic scans. Gadolinium enhancement of multiple sclerosis plaques correlated with the clinical activity of the disease and corresponded anatomically with the symptoms and signs. We conclude that gadolinium enhancement of magnetic resonance images is a promising tool in the investigation of multiple sclerosis lesions and that it may provide a method for objective follow-up in clinical trails.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Brain / pathology*
  • Contrast Media*
  • Drug Combinations / adverse effects
  • Female
  • Gadolinium DTPA
  • Gadolinium* / adverse effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Meglumine* / adverse effects
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / pathology
  • Organometallic Compounds* / adverse effects
  • Pentetic Acid* / adverse effects
  • Sorbitol / analogs & derivatives*
  • Tomography, X-Ray Computed


  • Contrast Media
  • Drug Combinations
  • Organometallic Compounds
  • Sorbitol
  • Meglumine
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA