The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani

Biochem Pharmacol. 1987 Aug 15;36(16):2633-6. doi: 10.1016/0006-2952(87)90543-0.


Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.

MeSH terms

  • Alkylation
  • Animals
  • Choline / analogs & derivatives*
  • Leishmania donovani / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Phosphorylcholine / analogs & derivatives
  • Phosphorylcholine / pharmacology*
  • Structure-Activity Relationship


  • Phosphorylcholine
  • Choline