Delayed development of intimal lesions in cerebral arteries of spontaneously hypertensive rats subjected to a short-term atherogenic diet (TEM observations)

Appl Pathol. 1986;4(4):233-6.


In adult spontaneously hypertensive rats, subjected to an atherogenic diet (2% cholic acid in a 5% hypercholesterolic diet) for 19 weeks both aortic and carotid artery lesions were already detectable on TEM examination while the cerebral arteries did not show any lesions. Similar findings have been previously obtained in rabbits and in monkeys on atherogenic diets.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aorta / ultrastructure
  • Carotid Arteries / ultrastructure
  • Cerebral Arteries / cytology
  • Cerebral Arteries / pathology
  • Cerebral Arteries / ultrastructure*
  • Diet, Atherogenic*
  • Microscopy, Electron
  • Rats
  • Rats, Inbred SHR
  • Time Factors