An industry wide mortality study of chemical workers occupationally exposed to benzene. II. Dose response analyses

Br J Ind Med. 1987 Jun;44(6):382-95. doi: 10.1136/oem.44.6.382.

Abstract

The data presented in this paper show statistically significant dose response relations between cumulative exposure to benzene (ppm-months) and mortality from both all lymphopoietic cancer combined and leukaemia. Chemical workers with a cumulative exposure to benzene of at least 720 ppm-months experienced a relative risk of 3.93 for lymphatic and haematopoietic cancer when compared with workers with no occupational exposure. The dose response relation between cumulative exposure and non-Hodgkin's lymphopoietic cancer was of borderline statistical significance (p = 0.06). No dose response relation was detected for any other causes of death.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Benzene / adverse effects*
  • Chemical Industry*
  • Dose-Response Relationship, Drug
  • Humans
  • Leukemia / chemically induced
  • Leukemia / mortality
  • Lymphoma, Non-Hodgkin / chemically induced
  • Lymphoma, Non-Hodgkin / mortality
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced
  • Occupational Diseases / mortality*
  • Time Factors
  • United States

Substances

  • Benzene