Mycotoxins can cause inflammation and oxidative stress throughout the body, leading to a chronic disease often called Chronic Inflammatory Response Syndrome (CIRS). Its symptoms overlap with those of many chronic diseases, such as Mast Cell Activation Syndrome, and chronic infections, such as Borrelia. For suspected mycotoxin illness, developing an list of indicators is important. Taking a thorough history of a person's potential mold exposure at his or her current home, past residences, and work location is critical. After clarifying the person's clinical symptoms and exposure history, the practitioner can perform tests to confirm specific mycotoxin exposure and then can implement treatment plans.