Reflections on the kinetics of substrate binding

Biophys Chem. 1987 May 9;26(2-3):117-21. doi: 10.1016/0301-4622(87)80016-9.


The principle questions which are still being asked about enzyme-substrate complex formation are examined. Data for the maximum rates of collision complex formation are reviewed. The limitations of past experimental procedures and the potentialities of new approaches are discussed together with methods that allow the distinction between collision complexes and subsequent events.

MeSH terms

  • Enzymes / metabolism*
  • Kinetics
  • Mathematics
  • Models, Theoretical*
  • Protein Binding


  • Enzymes