Oral health and the presence of infectious microorganisms in hospitalized patients: a preliminary observational study

Adriana Silva da Costa Cruz; Yara Peixoto Fidelis; Danielly de Mendonça Guimarães; Herick Sampaio Muller; Vicente de Paulo Martins; Erica Negrini Lia

doi:10.1080/07853890.2022.2092895

Oral health and the presence of infectious microorganisms in hospitalized patients: a preliminary observational study

Ann Med. 2022 Dec;54(1):1908-1917. doi: 10.1080/07853890.2022.2092895.

Authors

Adriana Silva da Costa Cruz¹, Yara Peixoto Fidelis², Danielly de Mendonça Guimarães², Herick Sampaio Muller³, Vicente de Paulo Martins³, Erica Negrini Lia^{1

2}

Affiliations

¹ Postgraduate Program in Dentistry, University of Brasília, Brasília, Brazil.
² Faculty of Health Sciences, Dentistry Department, University of Brasília, Brasília, Brazil.
³ Laboratory of Molecular Analysis of Pathogens, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.

Abstract

Objective: Characterise oral health, and the presence in the oral cavity of pathogenic non-oral microorganisms potentially associated with nosocomial infections and antimicrobial resistance in non-intubated patients admitted to a Brazilian university hospital.

Materials and methods: An intraoral examination and oral swab were performed on hospitalized individuals at three different times, T1 (within 48 h of hospitalization), T2 (48 h after T1) and T3 (7 days after hospitalization). The oral health status was defined by the Oral Health Assessment Tool (OHAT) and Tongue Coating Status (TCS). The swabs were processed and microorganisms potentially related to nosocomial infections were phenotypically identified through colony morphology, staining and microscopy.

Results: The most prevalent microorganisms were Escherichia coli, Enterococcus spp., Enterobacter spp., Pseudomonas spp., Candida albicans and Staphylococcus aureus. The oral health status was considered median, and the tongue coating index was considered high throughout the study period. The prevalence of potentially pathogenic non-oral microorganisms was high and constant from the first 48 h to the seventh day of hospitalization.

Conclusions: The results point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings, even in patients without mechanical ventilation, thus increasing the risk of nosocomial infections in susceptible individuals. KEY MESSAGESThe present study investigated the oral health status and the presence of pathogenic non-oral microorganisms in the oral cavity of patients hospitalized in the ward, non-intubated and mostly independent of self-care.The presence in the mouth of microorganisms related to the epidemiology of nosocomial infections and resistance to antimicrobials was high and constant from the first 48 h to the 7th day of hospitalization.The results of this study point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings even in patients without mechanical ventilation, increasing the risk of nosocomial infections in susceptible individuals.

Keywords: Hospitalization; microbiota; mouth; oral health.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Communicable Diseases*
Cross Infection* / epidemiology
Humans
Oral Health
Staphylococcal Infections*
Staphylococcus aureus

Grants and funding

This study received financial assistance from Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and from the Dean of Graduate Studies at the University of Brasília with funds from the PROAP program – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).