Abstract
We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. This result shows that striatal GABA differentially modulates the threshold for limbic seizures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amygdala / physiopathology*
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Animals
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Bicuculline / analogs & derivatives*
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Bicuculline / pharmacology
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Caudate Nucleus / drug effects*
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Electric Stimulation
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Electroencephalography
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Kindling, Neurologic / drug effects*
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Male
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Microinjections
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Putamen / drug effects*
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Rats
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Rats, Inbred Strains
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gamma-Aminobutyric Acid / physiology
Substances
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bicuculline methiodide
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gamma-Aminobutyric Acid
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Bicuculline