Microinjections of the gamma-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats

Brain Res. 1987 May 19;411(2):370-2. doi: 10.1016/0006-8993(87)91089-4.

Abstract

We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. This result shows that striatal GABA differentially modulates the threshold for limbic seizures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / physiopathology*
  • Animals
  • Bicuculline / analogs & derivatives*
  • Bicuculline / pharmacology
  • Caudate Nucleus / drug effects*
  • Electric Stimulation
  • Electroencephalography
  • Kindling, Neurologic / drug effects*
  • Male
  • Microinjections
  • Putamen / drug effects*
  • Rats
  • Rats, Inbred Strains
  • gamma-Aminobutyric Acid / physiology

Substances

  • bicuculline methiodide
  • gamma-Aminobutyric Acid
  • Bicuculline