[Effect of acupuncture intervention at different time points on the pregnancy rate of frozen embryo transfer]

Zhongguo Zhen Jiu. 2022 Sep 12;42(9):987-90. doi: 10.13703/j.0255-2930.20210625-0005.
[Article in Chinese]

Abstract

Objective: To observe the difference in the efficacy of acupuncture intervention at different time points on the pregnancy rate of in vitro fertilization-frozen embryo transfer (IVF-FET).

Methods: Ninety-nine patients with secondary infertility who were going to receive IVF-FET were divided into a transplantation-day acupuncture group, a transplantation cycle acupuncture group, and a non-acupuncture group according to their wishes, with 33 cases in each group. All three groups of patients received conventional IVF-FET treatment. The transplantation-day acupuncture group received acupuncture treatment 1 h before and 30 min after the embryo transfer, and the transplantation cycle acupuncture group received acupuncture treatment 5 weeks before the FET (once a week, 5 times) and on the day of transplantation, Zigong (EX-CA 1), Guanyuan (CV 4), Taichong (LR 3), Hegu (LI 4), etc. were selected in the two groups. The biochemical pregnancy rate and clinical pregnancy rate in the three groups were compared.

Results: The biochemical pregnancy rate and clinical pregnancy rate in the transplantation cycle acupuncture group were higher than those in the non-acupuncture group (P<0.05). There was no statistical difference in the biochemical pregnancy rate and clinical pregnancy rate between the transplantation cycle acupuncture group and the transplantation-day acupuncture group, and between the transplantation-day acupuncture group and the non-acupuncture group (P>0.05).

Conclusion: Acupuncture during the transplantation cycle can effectively improve the pregnancy rate of secondary infertility patients receiving IVF-FET.

目的:观察不同时间点针刺干预对体外受精-冻融胚胎移植(IVF-FET)妊娠率的影响。方法:将99例拟接受IVF-FET的继发性不孕患者按意愿分为移植日针刺组、移植周期针刺组和非针刺组,每组33例。3组患者均接受常规IVF-FET程序。移植日针刺组于FET当日移植前1 h与移植后30 min内行针刺治疗;移植周期针刺组于FET前5周(每周治疗1次,共5次)及移植当日行针刺治疗,均穴取子宫、关元、太冲、合谷等。比较3组患者生化妊娠率与临床妊娠率。结果:移植周期针刺组生化妊娠率及临床妊娠率均高于非针刺组(P<0.05);移植周期针刺组与移植日针刺组、移植日针刺组与非针刺组生化妊娠率及临床妊娠率比较,差异均无统计学意义 (P>0.05)。结论:移植周期针刺可有效提高接受IVF-FET的继发性不孕患者妊娠率。.

Keywords: acupuncture; biochemical pregnancy rate; clinical pregnancy rate; frozen embryo transfer; infertility.

MeSH terms

  • Acupuncture Therapy*
  • Embryo Transfer
  • Female
  • Fertilization in Vitro
  • Humans
  • Infertility*
  • Pregnancy
  • Pregnancy Rate