Ferroptosis, novel therapeutics in asthma

Biomed Pharmacother. 2022 Sep;153:113516. doi: 10.1016/j.biopha.2022.113516. Epub 2022 Aug 6.

Abstract

Ferroptosis, an iron-dependent form of regulated cell death, was recently demonstrated to be closely associated with the immune system. Regulators of ferroptosis may be the cells and secretions of the immune system. Ferroptosis has contributed to the progression of various diseases, namely, cancer, ischemia, and degenerative diseases. However, research on the relationship between ferroptosis and asthma remains fragmented. Non-immune cells associated with asthma are also closely associated with ferroptosis. Further studies on cross-linking asthma inflammation with ferroptosis signaling pathways could help identify several key molecules, known as ferroptosis regulators, that regulate asthma. Ferroptosis provides a new perspective to interpret and understand the manifestations of asthma, potential drug discovery targets, and new therapeutic options to effectively intervene in the imbalance caused by abnormal inflammation in asthma. Thus, the pathogenesis of ferroptosis and its contribution to the pathogenesis of asthma is essential in deepening the understanding and improving the prognosis and cure rate of the patients. Herein, we introduce the main molecular mechanisms of ferroptosis and asthma, describe the relationship between ferroptosis and asthma based on their common regulatory cells or molecules, and discuss potential drug discovery targets and therapeutic applications of ferroptosis in the context of immunomodulation and symptom alleviation.

Keywords: Asthma; Asthmatic inflammation; Ferroptosis; Regulators; Therapeutic applications.

Publication types

  • Review

MeSH terms

  • Asthma* / drug therapy
  • Ferroptosis*
  • Humans
  • Inflammation / drug therapy
  • Iron / metabolism
  • Signal Transduction

Substances

  • Iron