Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease

Ling Zhang; Qian Liu; Haoran Hu; Lu Zhao; Keyang Zhu

doi:10.1016/j.biopha.2022.113482

Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease

Biomed Pharmacother. 2022 Sep:153:113482. doi: 10.1016/j.biopha.2022.113482. Epub 2022 Aug 1.

Authors

Ling Zhang¹, Qian Liu², Haoran Hu¹, Lu Zhao¹, Keyang Zhu³

Affiliations

¹ College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
² College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
³ Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang, China. Electronic address: zhukeyang@nbu.edu.cn.

PMID: 36076582
DOI: 10.1016/j.biopha.2022.113482

Abstract

Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.

Keywords: Mesenchymal stem cells; Mitochondrial transfer; Tissue damage.

Publication types

Review

MeSH terms

Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells* / metabolism
Mitochondria