DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis

Int J Mol Sci. 2022 Aug 26;23(17):9711. doi: 10.3390/ijms23179711.


DOG1 is a transmembrane protein originally discovered on gastrointestinal stromal tumors and works as a calcium-activated chloride channel protein. There are a limited number of articles on the potential utility of this antibody in the diagnosis of salivary gland tumors in routine practice. In this study, we aimed to investigate the role of DOG1 as an immunohistochemical marker in patients with salivary acinic cell carcinoma (ACC) through meta-analysis. A literature search was performed of the PubMed, Scopus, and Web of Science databases for English-language studies published from January 2010 to September 2021. The literature search revealed 148 articles, of which 20 were included in the study. The overall rate of DOG1 expression in salivary acinic cell carcinoma was 55% (95% CI = 0.43-0.58). Although ACC is a challenging diagnosis, paying careful attention to the cytomorphological features in conjunction with DOG1 immunostaining can help to reach an accurate diagnosis.

Keywords: DOG1; acinic cell carcinoma; immunomarkers; salivary gland.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Carcinoma, Acinar Cell* / diagnosis
  • Carcinoma, Acinar Cell* / pathology
  • Chloride Channels
  • Humans
  • Salivary Gland Neoplasms* / metabolism


  • Biomarkers, Tumor
  • Chloride Channels

Grants and funding

This research received no external funding.