Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis

Int J Mol Sci. 2022 Sep 1;23(17):9971. doi: 10.3390/ijms23179971.


Cancer is a set of diseases characterized by several hallmark properties, such as increased angiogenesis, proliferation, invasion, and metastasis. The increased angiogenic activity constantly supplies the tumors with nutrients and a plethora of cytokines to ensure cell survival. Along these cytokines is a newly discovered protein, called irisin, which is released into the circulation after physical exercise. Irisin is the product of fibronectin type III domain-containing protein 5 (FNDC5) proteolytic cleavage. Recently it has been the topic of investigation in several types of cancer. In this study, we conducted a systematic review and meta-analysis to investigate its implication in different types of cancer. Our results suggest that irisin expression is decreased in cancer patients, thus it can be used as a valid biomarker for the diagnosis of several types of cancer. In addition, our results indicate that irisin may have an important role in tumor progression and metastasis since it is involved in multiple signaling pathways that promote cell proliferation and migration.

Keywords: cancers; irisin; physical exercise; thermogenesis.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Cytokines
  • Exercise
  • Fibronectins* / metabolism
  • Humans
  • Neoplasms*
  • Transcription Factors


  • Cytokines
  • FNDC5 protein, human
  • Fibronectins
  • Transcription Factors

Grants and funding

This research received no external funding.