Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review

Nutrients. 2022 Aug 26;14(17):3519. doi: 10.3390/nu14173519.


Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: ("resveratrol" AND "bone"); ("curcumin" AND "bone"); ("quercetin" AND "bone"). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.

Keywords: bone metabolism; bone tumours; diabetes; flavonoids; microbiota; oralbiotica; oralbiotics; osteoporosis; periodontitis; polyphenols.

Publication types

  • Systematic Review

MeSH terms

  • Curcumin* / chemistry
  • Curcumin* / pharmacology
  • Dietary Supplements
  • Humans
  • Osteoporosis* / drug therapy
  • Osteoporosis* / prevention & control
  • Periodontitis*
  • Quercetin / chemistry
  • Quercetin / pharmacology
  • Resveratrol / pharmacology


  • Quercetin
  • Curcumin
  • Resveratrol