Application of homologous fibronectin to persistent human corneal epithelial defects

Cornea. 1987;6(2):128-30. doi: 10.1097/00003226-198706020-00005.


Six eyes with persistent corneal epithelial defects of various etiologies were treated in a randomized, prospective, double-masked study to evaluate the effect of fibronectin on corneal epithelial wound healing. Study eyes received homologous human fibronectin (300 micrograms/ml), mixed with gentamicin and artificial tears, 4 times a day. Control eyes received the mixture of gentamicin and artificial tears. If no healing occurred after 2 weeks, the drug was unmasked and where control drops had been given, the mixture containing fibronectin was administered in open-label fashion. All 4 eyes in diabetic patients had successful epithelial healing when treated with the fibronectin solution. The 2 remaining corneas, which had defects secondary to a thermal injury and a presumed infectious etiology, did not heal with fibronectin.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Corneal Diseases / drug therapy*
  • Corneal Diseases / etiology
  • Diabetes Complications
  • Double-Blind Method
  • Drug Evaluation
  • Epithelial Cells
  • Epithelium / drug effects
  • Female
  • Fibronectins / pharmacology
  • Fibronectins / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Random Allocation
  • Wound Healing / drug effects*


  • Fibronectins