Effect of phytate on hypercalciuria secondary to bone resorption in patients with urinary stones: pilot study

Urolithiasis. 2022 Dec;50(6):685-690. doi: 10.1007/s00240-022-01357-8. Epub 2022 Sep 10.


The objective is to evaluate the effect of phytate supplements on calciuria in patients with urinary stones and elevated bone resorption. The secondary objective is to analyze the therapeutic effect of phytate based on measurements of serum markers of bone resorption. This is a controlled randomized study included patients according to predefined inclusion and exclusion criteria, and randomized them into two groups. Patients in the phytate group received a 380 mg capsule of calcium-magnesium InsP6 (Salvat Laboratories®) every 24 h for 3 months and patients in the control group received no treatment. All included patients were male or female, 18-65 years old, had hypercalciuria (> 250 mg/24 h), had a ß-Crosslaps level greater than 0.4 ng/mL, and had bone densitometry results indicative of osteopenia or osteoporosis in the femur and/or spine. At study onset, calciuria was 321 ± 52 mg/24 h in the phytate group and 305 ± 57 mg/24 h in the control group (p > 0.05). At 3 months, calciuria was significantly lower in the phytate group than the control group (226 ± 45 mg/24 h vs. 304 ± 58 mg/24 h, p < 0.05). At study onset, the mean ß-CrossLaps level was 1.25 ± 0.72 ng/mL in the phytate group and 0.57 ± 0.13 ng/mL in the control group (p < 0.05). However, at 3 months, the ß-CrossLaps level was significantly lower in the phytate group than in the control group (0.57 ± 0.13 ng/mL vs. 0.77 ± 0.42 ng/mL, p < 0.05). Phytate reduced calciuria in patients with hypercalciuria secondary to bone resorption. The ß-CrossLaps assay was effective for evaluating the efficacy of phytate on hypercalciuria during follow-up.

Keywords: Bone resorption; Hypercalciuria; Lithiasis; Phytate.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers
  • Bone Resorption* / complications
  • Calcium / urine
  • Female
  • Humans
  • Hypercalciuria / complications
  • Magnesium
  • Male
  • Middle Aged
  • Phytic Acid / therapeutic use
  • Pilot Projects
  • Urinary Calculi* / complications
  • Urolithiasis* / complications
  • Young Adult


  • Phytic Acid
  • Calcium
  • Magnesium
  • Biomarkers