MicroRNA-96 in human cancers

Comb Chem High Throughput Screen. 2022 Sep 9. doi: 10.2174/1386207325666220909104803. Online ahead of print.


MicroRNAs (miRNAs) are small non-coding RNAs 19-25 nucleotides in size involves in gene regulation and diverse processes in tumor cells. Abnormal expression of miRNAs is closely related to carcinogenesis. MiR-96 has been shown to be a salient cancer-related miRNA in a variety of tumors. Recent evidences indicates that miR-96 has been observed to be wrapped in exosome and associated with drug resistance or radio-chemosensitivity in cancers. miR-96 is also inextricably linked with the competing endogenous RNAs (ceRNAs) in cancers. Notably, miR-96 plays both a tumor suppressor role and plays a carcinogenic role in the same cancers. This review summarizes the critical role of cancer-related miR-96 in drug resistance or radio-chemosensitivity, and ceRNA mechanisms of miR-96 in cancer. And we innovatively propose that miR-96 has yin-yang effect in cancers. Based on these several major roles of miR-96 in cancer as described above, we speculate that the abnormal expression of miR-96 is likely to be a novel potential therapeutic targets in cancers. It is expected to solve the treatment problems such as low chemoradiotherapy sensitivity, poor prognosis quality of life and easy recurrence in cancer patients.

Keywords: MiR-96; cancer; ceRNAs; drug resistance; exosome; radio-chemosensitivity.