Is There a Place for Hyperbaric Oxygen Therapy?

Adv Surg. 2022 Sep;56(1):169-204. doi: 10.1016/j.yasu.2022.02.011.


Hyperbaric oxygen therapy (HBOT) involves treating patients by providing 100% oxygen through inhalation while inside a treatment pressurized chamber. The oxygen acts as a drug and the hyperbaric chamber as the dosing device. The effect of hyperbaric hyperoxia is dose dependent and, therefore, treatment depth and duration are important when considering its use. HBOT can either be the primary method of treatment or used adjunctively to medications or surgical techniques. The underpinning physiology is to bring oxygen-rich plasma to hypoxic tissue, preventing reperfusion injury, strengthening immune responsiveness, and encouraging new collagen deposition as well as endothelial cell formation.

Keywords: Hyperbaric chamber; Hyperbaric oxygen therapy; Hypoxia; Inhalation.

Publication types

  • Review

MeSH terms

  • Humans
  • Hyperbaric Oxygenation* / methods
  • Oxygen


  • Oxygen