Nonproliferative diabetic retinopathy with significant capillary nonperfusion

Graefes Arch Clin Exp Ophthalmol. 1987;225(3):157-9. doi: 10.1007/BF02175440.


A clinical study was carried out in 80 eyes of 50 diabetic patients with significant capillary nonperfusion at least in one eye. Panoramic photography of the fundus and wide-angle composite fluorescein angiography was performed in all cases. Forty-nine patients had type II diabetes. The mean age of the patients was 60 years and the mean duration of diabetes was 12.1 years; 46% of the patients had hypertensive vascular disease. Small neovascular tufts were observed in the iris sphincter in 20% of eyes. In addition, abnormal leakage of dye was observed in these eyes. Abnormal leakage of dye from the iris vessels was also observed in 9 of 20 eyes without clinically visible neovascularization. Numerous soft exudates distributed in a semicircular arc pattern were observed in 49% of eyes. Soft exudates were isolated and scarce in 37% of cases and were completely absent in 14% of eyes. Thus, in a substantial proportion of cases, the severity of the retinopathy could not be assessed by ophthalmoscopic findings alone.

MeSH terms

  • Adult
  • Aged
  • Capillaries / physiopathology*
  • Diabetic Retinopathy / pathology
  • Diabetic Retinopathy / physiopathology*
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Iris / pathology
  • Middle Aged
  • Regional Blood Flow