Synaptic tagging: homeostatic plasticity goes Hebbian

EMBO J. 2022 Oct 17;41(20):e112383. doi: 10.15252/embj.2022112383. Epub 2022 Sep 13.


Distinct plasticity mechanisms enable neurons to effectively process information also when facing global perturbations in network activity. In this issue of The EMBO Journal, Dubes et al (2022) provide a molecular mechanism whereby individual synapses during periods of chronic inactivity are "tagged" for future strengthening. These results lend further support to the idea that local, nonmultiplicative mechanisms play an important role in homeostatic synaptic plasticity as has been demonstrated for Hebbian-like synaptic plasticity.

Keywords: dendritic spine; homeostatic plasticity; microRNA; synaptic scaling; synaptopodin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Homeostasis / physiology
  • Neuronal Plasticity* / physiology
  • Neurons / physiology
  • Synapses* / physiology