CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer

Binhan Wang; Manni Wang; Danyi Ao; Xiawei Wei

doi:10.1016/j.bbcan.2022.188799

CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer

Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188799. doi: 10.1016/j.bbcan.2022.188799. Epub 2022 Sep 11.

Authors

Binhan Wang¹, Manni Wang¹, Danyi Ao¹, Xiawei Wei²

Affiliations

¹ Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
² Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. Electronic address: xiaweiwei@scu.edu.cn.

PMID: 36103908
DOI: 10.1016/j.bbcan.2022.188799

Abstract

Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, builds a signaling network that regulates not only normal organisms but also the development of many diseases. However, the precise action mechanism remains unclear. In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its association with diseases. For certain refractory diseases, we emphasize the diagnostic and therapeutic role of CXCL13-CXCR5 axis.

Keywords: Autoimmune disease; CXCL13-CXCR5; Cancer progression; Infectious disease; TLO.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chemokine CXCL13* / genetics
Humans
Ligands
Neoplasms* / genetics
Receptors, CXCR5 / genetics
Signal Transduction

Substances

CXCL13 protein, human
CXCR5 protein, human
Chemokine CXCL13
Ligands
Receptors, CXCR5