Clinical features of pediatric IgA Vasculitis patients with scrotal involvement

Mod Rheumatol. 2022 Sep 15;roac111. doi: 10.1093/mr/roac111. Online ahead of print.


Objectives: Immunoglobulin (Ig) A vasculitis (IgAV), the most common vasculitis of childhood. Scrotal involvement is relatively rare. In this study, we aimed to reveal the clinical and laboratory characteristics of patients with scrotal involvement in IgAV and its relationship with other clinical features of the disease.

Methods: A total number of 301 male patients with a diagnosis of IgAV between January 2005-2022 were retrospectively analyzed. The patients were divided into two groups as with and without scrotal involvement. The clinical and laboratory characteristics of the groups were compared.

Results: Scrotal involvement was detected in 16.3% (49) of male IgAV patients. Scrotal involvement was unilateral in 51% of patients. While single acute scrotal attack was present in 93.9% of patients, only 3 patients had recurrent acute scrotal involvement. In patients with scrotal involvement, the age at diagnosis was younger (p = 0.007) and disease recurrence was higher (p = 0.003). Glucocorticoid use was more common in patients with scrotal involvement (p < 0.001). In multivariable analysis, a statistically significant relation between scrotal involvement and age at diagnosis (OR = 0.85,95% CI0.76-0.96 p = 0.006) was detected.

Conclusions: In IgAV patients with scrotal involvement, the age at diagnosis is lower, steroid use is more common, and recurrent disease is more frequent.

Keywords: Age at diagnosis; IgA vasculitis; recurrent disease; scrotal involvement; steroid use.