Studies on new antibiotics SF2415. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

T Shomura; S Gomi; M Ito; J Yoshida; E Tanaka; S Amano; H Watabe; S Ohuchi; J Itoh; M Sezaki

doi:10.7164/antibiotics.40.732

Studies on new antibiotics SF2415. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

J Antibiot (Tokyo). 1987 Jun;40(6):732-9. doi: 10.7164/antibiotics.40.732.

Authors

T Shomura, S Gomi, M Ito, J Yoshida, E Tanaka, S Amano, H Watabe, S Ohuchi, J Itoh, M Sezaki, et al.

PMID: 3610830
DOI: 10.7164/antibiotics.40.732

Abstract

A new species of Streptomyces is described for which the name Streptomyces aculeolatus is proposed. The organism produces new antibiotics SF2415A1, A2, A3, B1, B2 and B3 active against Gram-positive bacteria. Empirical molecular formulae of the antibiotics SF2415A1, A2, A3, B1, B2 and B3 were determined to be C26H31N2O5Cl, C26H30N2O5, C26H30N2O5Cl2, C26H33O5Cl, C26H32O5 and C26H32O5Cl2, respectively.

MeSH terms

Animals
Anti-Bacterial Agents
Chemical Phenomena
Chemistry, Physical
Fermentation
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Kinetics
Lethal Dose 50
Mass Spectrometry
Mice
Naphthoquinones / biosynthesis*
Naphthoquinones / isolation & purification
Naphthoquinones / pharmacology
Spectrophotometry
Streptomyces / classification
Streptomyces / isolation & purification
Streptomyces / metabolism*

Substances

Anti-Bacterial Agents
Naphthoquinones