Shedding Light on Amoxicillin, Amoxicillin-clavulanate, and Cephalexin Dosing in Children from a Pharmacist's Perspective

J Pediatric Infect Dis Soc. 2022 Dec 28;11(12):594-602. doi: 10.1093/jpids/piac105.


Selection of an antibiotic and dosing regimen requires consideration of multiple factors including microbiological data, site of infection, pharmacokinetics, and how it relates to the pharmacodynamic target. Given the multiple dosage regimens of amoxicillin with/without clavulanate and cephalexin, we review the principles of dose selection from a pharmacist's perspective.

Keywords: dose formulation; osteomyelitis; pediatric dosing; pharmacokinetics/pharmacodynamics; pneumonia.

Publication types

  • Review

MeSH terms

  • Amoxicillin*
  • Amoxicillin-Potassium Clavulanate Combination / therapeutic use
  • Anti-Bacterial Agents
  • Cephalexin* / therapeutic use
  • Child
  • Clavulanic Acid / pharmacokinetics
  • Humans
  • Microbial Sensitivity Tests
  • Pharmacists


  • Amoxicillin
  • Cephalexin
  • Amoxicillin-Potassium Clavulanate Combination
  • Anti-Bacterial Agents
  • Clavulanic Acid