Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper

ASN Neuro. 2022 Jan-Dec:14:17590914221126367. doi: 10.1177/17590914221126367.


The demyelinating effects of CPZ are not due to Cu deficiency but are instead consistent with acute toxicity of a CPZ + Cu complex.

Keywords: cuprizone; demyelination; multiple sclerosis; neurodegeneration; penicillamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain
  • Copper / toxicity
  • Cuprizone* / toxicity
  • Demyelinating Diseases* / chemically induced
  • Disease Models, Animal
  • Mice
  • Mice, Inbred C57BL


  • Cuprizone
  • Copper

Grants and funding