Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission: a retrospective cohort study

Int J Clin Pharm. 2022 Oct;44(5):1205-1210. doi: 10.1007/s11096-022-01447-y. Epub 2022 Sep 17.

Abstract

Background: Of all hospital admissions in older patients, 10-30% seem to be medication-related. However, medication-related admissions are often unidentified in clinical practice. To increase the identification of medication-related hospital admissions in older patients a triggerlist is published in the Dutch guideline for polypharmacy.

Aim: To assess whether the triggerlist has value as selection criterion to identify patients at high risk of medication-related hospital admissions.

Method: This retrospective cohort study was carried out in 100 older (≥ 60 years) patients with polypharmacy and having two triggers from the triggerlist. The admissions were assessed as either possibly or unlikely medication-related according to the Assessment Tool for identifying Hospital Admissions Related to Medications.

Results: Of all the admissions 48% were classified as possibly medication-related. Patients with a possible medication-related hospital admission were more likely to have an impaired renal function (p = 0.015), but no differences with regard to age, sex, comorbidity or number of medicines were found.

Conclusion: The high prevalence of medication-related hospital admissions, suggests the triggerlist may have added value as selection criterion in a cohort of older patients with polypharmacy and can be used to improve the identification of a population at high risk of medication-related hospital admissions.

Keywords: Aged; Hospitalization; Medication errors; Polypharmacy; Triggerlist.

MeSH terms

  • Aged
  • Cohort Studies
  • Hospitalization*
  • Hospitals
  • Humans
  • Polypharmacy*
  • Retrospective Studies