Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases

Kenneth Blum; David Han; David Baron; Shan Kazmi; Igor Elman; Luis Llanos Gomez; Marjorie C Gondre-Lewis; Panyotis K Thanos; Eric R Braverman; Rajendra D Badgaiyan

doi:10.2174/2666082218666220527114427

Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases

Curr Psychiatry Res Rev. 2022 Jul;18(2):125-143. doi: 10.2174/2666082218666220527114427. Epub 2022 Jun 21.

Authors

Kenneth Blum^{1

2

3

4

5

6

7

8}, David Han⁹, David Baron^{3

8}, Shan Kazmi⁸, Igor Elman⁹, Luis Llanos Gomez², Marjorie C Gondre-Lewis¹⁰, Panyotis K Thanos¹¹, Eric R Braverman⁷, Rajendra D Badgaiyan^{12

13}

Affiliations

¹ Division of Addiction Research & Education, Center for Psychiatry, Medicine, & Primary Care (office of the Provost) Western University Health Sciences, Pomona, CA., USA.
² The Kenneth Blum Institute of Behavioral & Neurogenetics, Austin, TX, USA.
³ Department of Psychology, University of Buffalo, the State University of New York, Buffalo, NY, United States.
⁴ Institute of Psychology, ELTE Eotvos Loránd University, Budapest, Hungary.
⁵ Department of Psychiatry, Wright University, Boonshoft School of Medicine, Dayton, OH, USA.
⁶ Department of Psychiatry, University of Vermont, Burlington, VT., USA.
⁷ Division of Clinical Neurology, PATH Foundation NY., New York, USA.
⁸ College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
⁹ Department of Management Science and Statistics, University of Texas at San Antonio, Texas, USA; Center for Pain and the Brain, Department of Anesthesia, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts General Hospital and McLean Hospital, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Anatomy & Psychiatry, Howard University School of Medicine, Washington, DC., USA.
¹¹ Department of Psychology & Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, and Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.
¹² Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, NY, USA.
¹³ Department of Psychiatry, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.

Abstract

Background: There is a shortage of clinical studies examining the efficacy of Nicotinamide Adenine Dinucleotide and Enkephalinase infusions (IV1114589NAD) in treating Substance Use Disorder (SUD).

Objective: This study aims to provide evidence that IV1114589NAD infusions significantly attenuate substance craving behavior.

Methods: The study cohort consisted of addicted poly-drug, mixed gender, multi-ethnic individuals resistant to standard treatment. The investigation utilized Likert-Scales to assess behavioral outcomes.

Results: Using Wilcoxon signed-rank tests and sign tests, our team detected significant results by comparing baseline to post outcome scores after IV1114589NAD injections: craving scores (P=1.063E-9); anxiety (P=5.487E-7); and depression (P=1.763E-4). A significant reduction in cravings, anxiety, and depression followed a dose-dependent linear trend. Linear trend analyses showed a significant relationship between NAD infusions and decreasing scores for cravings (P=0.015), anxiety (P=0.003), and depression (P=8.74E-5). A urine analysis was conducted on a subset of 40 patients midway through the study to assess relapse; 100% of the urine samples analyzed failed to detect illicit substance use.

Discussion: The opioid crisis in America has claimed close to 800,000 lives since 2004; daily deaths are estimated to stand at 127, and in 2021, over 107,000 deaths were due to overdose. There is an urgency to find safe, side-effect-free solutions. Current interventions, such as Naltrexone implants, are invasive and may interfere with dopamine homeostasis leading to an anti-reward phenomenon. Larger randomized double-blinded placebo-controlled studies are needed to elucidate further the significance of the results presented in this study. The current pilot study provides useful preliminary data regarding the effectiveness of IV1114589NAD infusions in SUD treatment.

Conclusion: This pilot study provides significant evidence that NAD infusions are beneficial in the treatment of SUD. This investigation serves as a rationale to extend these findings onto future research investigating the use of NAD/NADH as a stand-alone treatment, especially in patients showing high genetic risk as measured in the Genetic Addiction Risk Severity (GARS) test. Utilizing GARS will help provide a real personalized therapeutic approach to treat Reward Deficiency Syndrome (RDS).

Keywords: Medication Assistant Treatment (MAT); Nicotinamide adenine dinucleotide (ND+) infusions; anxiety depression; cravings; dopamine homeostasis; reward deficiency syndrome (RDS).

Abstract

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