Drug utilization evaluation of pantoprazole in Kempegowda Institute of Medical Sciences (KIMS) hospital and research centre, India

J Family Med Prim Care. 2022 Jun;11(6):3138-3142. doi: 10.4103/jfmpc.jfmpc_1516_21. Epub 2022 Jun 30.

Abstract

Objective: To evaluate the rational use of Pantoprazole by analyzing the appropriateness of prescription.

Methodology: This cross-sectional study was performed within four months in 150 patients hospitalized in Kempegowda Institute of Medical Sciences Hospital and Research Centre, India. Demographic data, type and doses of Pantoprazole, including risk factors, and other relevant clinical data were recorded.

Result: Out of 150 prescriptions prescribed with Pantoprazole 102 prescriptions were prescribed along with Non-steroidal anti-inflammatory drugs (NSAIDs) and 90 prescriptions were prescribed along with antibiotics. The majority (78.7%) of the patients were endorsed with Pantoprazole. Following national institute for health and care excellence (NICE) rules, fitting utilization of protein pump inhibitors (PPIs) was found in 64% whereas it was unseemly to use in 36% of cases. A large portion of the potential medication sedate associations was moderate. Characterized everyday dose/100-bed day of PPIs was seen as 0.929. Rabeprazole (20 mg, tablet) demonstrated the most extreme rate value variety of 672.32% while Pantoprazole (40 mg, infusion) indicated a base rate value variety of 18.72%.

Conclusion: Prevalence of dosage shows that Pantoprazole was prescribed more for males in the age group of 60-70 years with the significant risk factor of smoker (18%) and alcoholic (9.3%). Among 150 prescriptions, 22.67% of prescriptions were irrationally prescribed. PPIs should be used only when there is documented evidence and when their use is clinically justified so that the appropriate prescription of PPIs will decrease the social insurance weight of the patient.

Keywords: Drug utilization evaluation; NICE guidelines; PPIs; pantoprazole.