Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials

Eur J Med Chem. 2022 Dec 5:243:114735. doi: 10.1016/j.ejmech.2022.114735. Epub 2022 Sep 12.

Abstract

A series of ferrocenyl-containing γ-hydroxy-γ-lactam tetramates were prepared in 2-3 steps through ring opening-ring closure (RORC) process of γ-ylidene-tetronate derivatives in the presence of ferrocenyl alkylamines. The compounds were screened in vitro for their antiplasmodial activity against chloroquine-sensitive (3D7) and chloroquine-resistant (W2) clones of P. falciparum, displaying activity in the range of 0.12-100 μM, with generally good resistance index. The most active ferrocene in these series exhibited IC50 equal to 0.09 μM (3D7) and 0.12 μM (W2). The low cytotoxicity of the ferrocenyl-containing γ-hydroxy-γ-lactam tetramates against Human Umbilical Vein Endothelial (HUVEC) cell line demonstrated selective antiparasitic activity. The redox properties of these ferrocene-derived tetramates were studied and physico-biochemical studies evidenced that these derivatives can exert potent antimalarial activities via a mechanism distinct from ferroquine.

Keywords: Antimalarial; Fenton; Ferrocene; Lactam; ROS; Tetramate.

MeSH terms

  • Antimalarials* / chemistry
  • Chloroquine / therapeutic use
  • Humans
  • Lactams / chemistry
  • Lactams / pharmacology
  • Malaria, Falciparum* / drug therapy
  • Metallocenes / pharmacology
  • Plasmodium falciparum
  • Structure-Activity Relationship

Substances

  • ferrocene
  • Metallocenes
  • Antimalarials
  • Lactams
  • Chloroquine