Limits of Cardiovascular Adaptation During an Extreme Ultramarathon: Insights From Serial Multidimensional, Multiparametric CMR

JACC Case Rep. 2022 Sep 7;4(17):1104-1109. doi: 10.1016/j.jaccas.2022.05.028.


Extreme endurance athletic challenges provide unique opportunities to study the cardiovascular system's capacity for structural, functional, and hemodynamic adaptation. The authors present a case of a male subject who ran 2,469 km, with serial multiparametric cardiac magnetic resonance imaging used to demonstrate adaptive and maladaptive alterations in cardiac remodeling and myocardial tissue health. (Level of Difficulty: Advanced.).

Keywords: 3D-MDA, 3-dimensional myocardial deformation analysis; 4D-flow; 4D-flow, 4-dimensional flow analysis; CMR, cardiac magnetic resonance; ECV, extracellular volume; EDV, end-diastolic volume; ESV, end-systolic volume; LA, left atrium; LV, left ventricle; RV, right ventricular; cardiac magnetic resonance; strain analysis; tissue mapping.

Publication types

  • Case Reports