HMI-PRED 2.0: a biologist-oriented web application for prediction of host-microbe protein-protein interaction by interface mimicry

Hansaim Lim; Chung-Jung Tsai; Ozlem Keskin; Ruth Nussinov; Attila Gursoy

doi:10.1093/bioinformatics/btac633

HMI-PRED 2.0: a biologist-oriented web application for prediction of host-microbe protein-protein interaction by interface mimicry

Bioinformatics. 2022 Oct 31;38(21):4962-4965. doi: 10.1093/bioinformatics/btac633.

Authors

Hansaim Lim¹, Chung-Jung Tsai¹, Ozlem Keskin², Ruth Nussinov^{1

3}, Attila Gursoy⁴

Affiliations

¹ Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Cancer Innovation Laboratory, NCI-Frederick, Frederick, MD 21702, USA.
² Department of Chemical and Biological Engineering, Koç University, Istanbul 34450, Turkey.
³ Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
⁴ Department of Computer Engineering, Koç University, Istanbul 34450, Turkey.

Abstract

Summary: HMI-PRED 2.0 is a publicly available web service for the prediction of host-microbe protein-protein interaction by interface mimicry that is intended to be used without extensive computational experience. A microbial protein structure is screened against a database covering the entire available structural space of complexes of known human proteins.

Availability and implementation: HMI-PRED 2.0 provides user-friendly graphic interfaces for predicting, visualizing and analyzing host-microbe interactions. HMI-PRED 2.0 is available at https://hmipred.org/.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural

MeSH terms

Humans
Proteins* / chemistry
Software*
User-Computer Interface

Substances

Proteins

Grants and funding

HHSN261201500003I/CA/NCI NIH HHS/United States