Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor

Curr Drug Targets. 2022;23(16):1454-1456. doi: 10.2174/1389450123666220920111841.

Authors

Yajun Liu¹, Yajing Li¹

Affiliation

¹ School of Life and Pharmaceutical Sciences, Dalian University of Technology, Dagong Road 2, Liaodongwan District, Panjin 124221, China.

PMID: 36125840
DOI: 10.2174/1389450123666220920111841

No abstract available

Keywords: C-terminus; HSP90; L-cysteine; heat shock response; structure-based drug design; targeted covalent inhibition.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / pharmacology
Cell Line, Tumor
HSP90 Heat-Shock Proteins
Humans

Substances

Antineoplastic Agents
HSP90 Heat-Shock Proteins