Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios of overweight children and adolescents

Rev Assoc Med Bras (1992). 2022 Aug;68(8):1006-1010. doi: 10.1590/1806-9282.20211253.

Abstract

Objective: This study aimed to compare neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio of overweight children and adolescents with the eutrophic ratios and to verify whether these ratios are associated with age, inflammation, Z-score of body mass index, and waist-to-height ratio.

Methods: This is a cross-sectional study involving 64 overweight and 106 eutrophic children and adolescents. Data on weight, height, and waist circumference (body mass index and waist-to-height ratio), blood count (neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio), and high-sensitivity C-reactive protein were collected.

Results: The mean age of participants was 8.4±3.2 years. The ratios did not differ between the overweight and non-overweight groups. The platelet-to-lymphocyte ratio has shown a direct and independent association with body mass index (p=0.031) and waist-to-height ratio (p=0.018), a fact not observed for neutrophil-to-lymphocyte ratio. The ultrasensitive C-reactive protein level was higher in the obesity group (p=0.003). Both ratios had a direct and independent association with age.

Conclusion: The ratios did not differ between the overweight and non-overweight groups. There was a direct and independent association of platelet-to-lymphocyte ratio with overweight, not observed in neutrophil-to-lymphocyte ratio. The ratios have significantly increased according to the age of the participants.

MeSH terms

  • Adolescent
  • Body Mass Index
  • C-Reactive Protein*
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Humans
  • Lymphocytes
  • Neutrophils*
  • Overweight / complications
  • Risk Factors
  • Waist Circumference

Substances

  • C-Reactive Protein