Sensational astrocytes: Mechanotransduction in adult brain function

Neuron. 2022 Sep 21;110(18):2891-2893. doi: 10.1016/j.neuron.2022.08.007.


Sensing the mechanical microenvironment is an essential aspect of all life, yet its mechanism remains poorly understood. In this issue of Neuron, Chi et al. reveal the role of astrocyte mechanosensitive Piezo1 channel in adult neurogenesis and cognitive function.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Astrocytes* / metabolism
  • Brain / metabolism
  • Ion Channels* / metabolism
  • Mechanotransduction, Cellular / physiology
  • Neurogenesis


  • Ion Channels