Insights from multi-omics integration in complex disease primary tissues

Trends Genet. 2023 Jan;39(1):46-58. doi: 10.1016/j.tig.2022.08.005. Epub 2022 Sep 19.


Genome-wide association studies (GWAS) have provided insights into the genetic basis of complex diseases. In the next step, integrative multi-omics approaches can characterize molecular profiles in relevant primary tissues to reveal the mechanisms that underlie disease development. Here, we highlight recent progress in four examples of complex diseases generated by integrative studies: type 2 diabetes (T2D), osteoarthritis, Alzheimer's disease (AD), and systemic lupus erythematosus (SLE). High-resolution methodologies such as single-cell and spatial omics techniques will become even more important in the future. Furthermore, we emphasize the urgent need to include as yet understudied cell types and increase the diversity of studied populations.

Keywords: Alzheimer’s disease; multi-omics; osteoarthritis; primary tissue; systemic lupus erythematosus; type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2* / genetics
  • Genome-Wide Association Study*
  • Humans
  • Multiomics