Imaging Features of Intratumoral Injection of NBTXR3 for Head and Neck Squamous Cell Carcinoma Lymph Node Metastases

Daniel Thomas Ginat; Aditya Juloori; Omar I Vivar; Leonard A Farber; Zhen Gooi; Ari J Rosenberg

doi:10.3390/diagnostics12092156

Imaging Features of Intratumoral Injection of NBTXR3 for Head and Neck Squamous Cell Carcinoma Lymph Node Metastases

Diagnostics (Basel). 2022 Sep 5;12(9):2156. doi: 10.3390/diagnostics12092156.

Authors

Daniel Thomas Ginat¹, Aditya Juloori², Omar I Vivar³, Leonard A Farber³, Zhen Gooi⁴, Ari J Rosenberg²

Affiliations

¹ Department of Radiology, University of Chicago Medical Center, Chicago, IL 60637, USA.
² Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.
³ Department of Global Medical Affairs, Nanobiotix, 75012 Paris, France.
⁴ Department of Surgery, University of Chicago Medical Center, Chicago, IL 60637, USA.

Abstract

NBTXR3 nanoparticle injection is a relatively novel radioenhancer for treatment of various cancers. CT scans following NBTXR3 injection of metastatic lymph nodes from head and neck squamous cell carcinoma were reviewed in a small series of patients. The radioenhancing appears as hyperattenuating, with a mean attenuation of the injected material of 1516 HU. The material was found to leak beyond the margins of the tumor in some cases.

Keywords: NBTXR3; cancer; head and neck; injection; tumor.

Publication types

Case Reports

Grants and funding

This research received no external funding.