Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury

Medicina (Kaunas). 2022 Sep 1;58(9):1198. doi: 10.3390/medicina58091198.


Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression in monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes in sepsis. This study aimed to establish an association between AKI and HLA-DR expression in monocytes of patients with sepsis. Materials and Methods: We detected HLA-DR expression in monocytes and measured plasma levels of S100A12, high-mobility group box 1 (HMGB1), advanced glycation end products (AGE), and soluble receptor for AGE (sRAGE) from septic patients and healthy controls. Results: HLA-DR expression in monocytes was decreased in patients with AKI than in those without AKI (29.8 ± 5.0% vs. 53.1 ± 5.8%, p = 0.005). Compared with AKI patients, the mean monocyte HLA-DR expression in patients with end-stage renal disease was increased without statistical significance. There were no differences in the AGE/sRAGE ratio and plasma levels of S100A12, HMGB1, AGE, and sRAGE between patients with and without AKI. Conclusions: Compared with septic patients without AKI, patients with AKI had significantly lower HLA-DR expression in monocytes. The role of hemodialysis in monocyte HLA-DR expression needs further studies to explore.

Keywords: HLA-DR; acute kidney injury; monocyte; sepsis.

MeSH terms

  • Acute Kidney Injury*
  • Glycation End Products, Advanced
  • HLA-DR Antigens / metabolism
  • HMGB1 Protein* / metabolism
  • Humans
  • Monocytes
  • S100A12 Protein / metabolism
  • Sepsis* / complications


  • Glycation End Products, Advanced
  • HLA-DR Antigens
  • HMGB1 Protein
  • S100A12 Protein