Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome

Galia V Anguelova; Monique H M Vlak; Arthur G Y Kurvers; Roselyne M Rijsman

doi:10.1016/j.jsmc.2022.06.006

Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome

Sleep Med Clin. 2022 Sep;17(3):407-419. doi: 10.1016/j.jsmc.2022.06.006. Epub 2022 Sep 7.

Authors

Galia V Anguelova¹, Monique H M Vlak¹, Arthur G Y Kurvers¹, Roselyne M Rijsman²

Affiliations

¹ Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, the Netherlands.
² Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, the Netherlands. Electronic address: r.rijsman@haaglandenmc.nl.

PMID: 36150803
DOI: 10.1016/j.jsmc.2022.06.006

Abstract

Restless legs syndrome (RLS) is a sleep-related disorder defined by an urgency to move the legs, usually combined with uncomfortable or unpleasant sensations, which occurs or worsens during rest, usually in the evening or at night, and disappears with the movement of the legs. RLS can be classified as idiopathic or primary, and secondary to comorbid conditions (eg, renal disease, polyneuropathy). The pathophysiology of RLS is still unclear. This article provides an updated practical guide for the treatment of primary RLS in adults.

Keywords: Augmentation; Nonpharmacologic; Pharmacologic; Restless legs syndrome; Therapy; Treatment.

Publication types

Review

MeSH terms

Adult
Humans
Restless Legs Syndrome* / drug therapy