Exosomal noncoding RNAs in colorectal cancer: An overview of functions, challenges, opportunities, and clinical applications

Pathol Res Pract. 2022 Sep 17;238:154133. doi: 10.1016/j.prp.2022.154133. Online ahead of print.

Abstract

Colorectal cancer (CRC) is the third most threatening malignancy worldwide. Colorectal tumors transfer information with their tumor microenvironment (TME) and communicate together which can be detected through exosome transmission. Exosomes are important regulators made by different types of cells in all body fluids containing RNA, DNA, metabolites, and proteins. Recently, Exosome-derived noncoding RNAs (ncRNAs) applications have gained great consideration based on their potential role in the different pathological processes. Therefore, in this review, we summarized the recent discoveries on exosomal ncRNAs function in CRC initiation and development, and drug resistance to provide a novel insight into exosomal ncRNAs' clinical application and their potential to be biomarkers for CRC patients.

Keywords: Clinical application; Colorectal cancer; Exosome; NcRNAs.

Publication types

  • Review